中药复方血清药理研究方法学探讨——Ⅳ

崔晓兰; 周爱香; 贺玉琢; 高英杰; 李小芹; 田甲丽; 郭淑英; 霍海茹; 姜廷良

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中药复方血清药理研究方法学探讨——Ⅳ

更新时间：2024-09-23

- 中药复方血清药理研究方法学探讨——Ⅳ
- Study on Method of Serum-pharmacology of Compound-Prescription of Traditional Chinese Medicine——Ⅳ
- 中国实验方剂学杂志 2000年6卷第2期页码：23-25
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金重点项目（39630360）
- DOI：
  中图分类号：
- 纸质出版日期：2000
- 稿件说明：
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崔晓兰, 周爱香, 贺玉琢, 等. 中药复方血清药理研究方法学探讨——Ⅳ[J]. 中国实验方剂学杂志, 2000,6(2):23-25.

CUI Xiao-lan, ZHOU Ai-xiang, HE Yu-zhuo, et al. Study on Method of Serum-pharmacology of Compound-Prescription of Traditional Chinese Medicine——Ⅳ[J]. Chinese journal of experimental traditional medical formulae, 2000, 6(2): 23-25.
崔晓兰, 周爱香, 贺玉琢, 等. 中药复方血清药理研究方法学探讨——Ⅳ[J]. 中国实验方剂学杂志, 2000,6(2):23-25. DOI：

CUI Xiao-lan, ZHOU Ai-xiang, HE Yu-zhuo, et al. Study on Method of Serum-pharmacology of Compound-Prescription of Traditional Chinese Medicine——Ⅳ[J]. Chinese journal of experimental traditional medical formulae, 2000, 6(2): 23-25. DOI：

摘要

家兔灌胃桂枝汤，1日1次，连续3d给药以及1日2次，连续3d给药，末次给药后0．5～9h采血，分离血清，观察各含药血清对病毒致细胞病变作用的影响。结果：上述各方法制备的含药血清抗副流感病毒致CPE作用所表现出的有效时间点分别为：无明显有效时间点、4～5h、2h、5～7h、1～6h，1日2次给药3d及1日3次给药后采集的含药血清可引起培养细胞明显的退行性改变。

Abstract

Rabbits were dosed with Guizhi Tang once

twice and three times a day for one

two and three days

respectively.The rabbit blood was sampled after 0.5 to 9 hours of last dosing and serum was separated.Inhibitory effect of the contained-herb serum on cytopathy was observed.Compared with normal serum

the contained-herb serum of single dosing showed no inhibitory effect on cytopathy.The serum sampled from the 4th to 5th hour when dosing once a day for two day and that at the 2nd hour when dosing once a day for three days markedly showed inhibitory effect on cytopathy.The serum sampled from the 5th to 7th hour when dosing twice a day for one day and that from the 1st to 6th hour when dosing twice a day for two days also showed inhibitory effect on cytopathy.But when dosing twice a day for three days or three times a day

the serum sampled after administration could cause clear degeneration of culture cells.

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