Fu Hangyu, Guo Shuying, Zhou Asxiang. Mechanism Guixhi Decoction(桂枝汤) On Dual Directional Thermoregulation;Effect of Neurotensin and ACTH on Hypothermia[J]. Chinese Journal of Experimental Traditional Medical Formulae, 1995, 1(1): 11-14.
Fu Hangyu, Guo Shuying, Zhou Asxiang. Mechanism Guixhi Decoction(桂枝汤) On Dual Directional Thermoregulation;Effect of Neurotensin and ACTH on Hypothermia[J]. Chinese Journal of Experimental Traditional Medical Formulae, 1995, 1(1): 11-14.DOI:
Neurotensin and ACTH are neuropeptids as endogenous cryogensin central nervous system
BOdy temperature was rapidly decreased when[D-Tyr"]-neurotensin(NT) or ACTH was administered in cerebroventricular injec-tion(icv)in normal rats.The hypothermic action of NT was dose-dependentpattern and related to environmentaI temperature. Oral administration of 10gcrude drug/Kg Guizhi decoction(GZD)one hour before icv of NT could an-tagonize the hypothermia. But this antagonistic effect was not observed in the ex-periment with ACTH treatment.The results indicated that NT was involved inthe mechanism of dual directional thermoregulation by GZD
but the role ofACTH in the thermoregulation was unclear.