Objective: Study on the regularity oftriptolidedissolution in Qingluo Tongbi decoction to find the chemical basis related to Tripterygium wilfordii compatibility for attenuation. Method: Concentrations of triptolide in Qingluo Tongbi decoction and T. wilfordii combination groups were determined by HPLC binding component-knockout and forluma combination approach.Total components in T. wilfordii

T. wilfordii decoction

combined application of T. wilfordi and Notoginseng Radix et Rhizoma as well as T. wilfordii and Sinomenii Caulis were analyzed to find the dissolution difference of marjor elements between the combination groups. Result: The concentrations of triptolide werein the order under the same dose of T. wilfordii: the whole recipe exclude Notoginseng Radix et Rhizoma> the whole recipe exclude Sinomenii Caulis> whole recipe exclude Rehmanniae Radix> the whole recipe exclude Bombyx Batryticatus> the whole recipe; T. wilfordii and Sinomenii Caulis> T. wilfordii> T. wilfordii and Rehmanniae Radix> T. wilfordii and Bombyx Batryticatus> T. wilfordii and Radix Notoginseng et Rhizoma. The statistics analysis showed that Notoginseng Radix et Rhizoma significantly reduced the dissolving action of triptolide (P<0.05) while Sinomenii Caulis promoted its dissolution(P<0.05). The dissolubility rules of T. wilfordii in different groups based on total components analysis were in accord with that above. Conclusion: Based on the dissolution changes of chemical components of T. wilfordii due to compatibility in Qingluo Tongbi decoction

it could be preliminarily inferred that T. wilfordii induced toxicity could be decreased by combination of T. wilfordii and Notoginseng Radix et Rhizoma while increased when T. wilfordii and Sinomenii Caulis were used simultaneously

which provided exprimental basis of T. wilfordii combinations for attenuationin clinical therapy.