Objective: With total panax notoginsenosides from different formulations of Danqi prescription as a model

to explore new ideas and methods of in vitro dissolution study for multi-components from traditional Chinese medicine(TCM). Method: The small cup method was used with distilled water as dissolution medium at a rotate speed of 50 r·min-1

in vitro dissolution rates in the molar concentration of notoginsenoside Rl

ginsenoside Rb1 and ginsenoside Rg1 were determined by HPLC

and in vitro accumulative dissolution rate of total panax notoginsenosides in the molar concentration was calculated by taking percentage of each component in total panax notoginsenosides as self-defined weighting coefficient. Result: There were significant differences between dripping pills and tables in dissolution rate of notoginsenoside Rl

ginsenoside Rb1

ginsenoside Rg1 (96.87% vs 16.10%

97.15% vs 15.48% and 96.10% vs 16.03% at 30 min);In vitro molar dissolution rate of tables could up to 90% in 120 minutes.It showed that Td and T50 of total panax notoginsenosides and three components in dripping pills were more than tables

which were fitting by Weibull equation. Conclusion: These in vitro dissolution results was in line with in vitro analysis of similar ingredients in TCM

these obtained parameters could characterized in vitro overall release rules of similar substances in TCM.