延胡索乙素柔性脂质体的制备与透皮吸收

刘广; 齐娜; 孙考祥; 张延惠

doi:10.11653/syfj2013080037

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延胡索乙素柔性脂质体的制备与透皮吸收

更新时间：2024-01-04

- 延胡索乙素柔性脂质体的制备与透皮吸收
- Preparation and Transdermal Absorption of -tetrahydropalmatine Flexible Liposomes
- 中国实验方剂学杂志 2013年19卷第8期页码：37-39
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- DOI：10.11653/syfj2013080037
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- 纸质出版日期：2013
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刘广, 齐娜, 孙考祥, 等. 延胡索乙素柔性脂质体的制备与透皮吸收[J]. 中国实验方剂学杂志, 2013,19(8):37-39.

LIU Guang, QI Na, SUN Kao-xiang, et al. Preparation and Transdermal Absorption of -tetrahydropalmatine Flexible Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 37-39.
刘广, 齐娜, 孙考祥, 等. 延胡索乙素柔性脂质体的制备与透皮吸收[J]. 中国实验方剂学杂志, 2013,19(8):37-39. DOI： 10.11653/syfj2013080037.

LIU Guang, QI Na, SUN Kao-xiang, et al. Preparation and Transdermal Absorption of -tetrahydropalmatine Flexible Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 37-39. DOI： 10.11653/syfj2013080037.

摘要

目的: 制备延胡索乙素柔性脂质体

研究其透皮吸收效果。方法: 采用薄膜分散法制备延胡索乙素柔性脂质体

改良的Franz扩散池法研究其透皮吸收。结果: 制备的延胡索乙素柔性脂质体包封率82.7%

粒径(112.3±59.2) nm

基本呈正态分布。该制剂12 h内累积渗透量2 121 μg

明显高于对照组酊剂的1 153 μg;在皮肤内滞留率53.9%

明显高于酊剂的11.2%。结论: 制得的延胡索乙素柔性脂质体透皮效果较酊剂好。

Abstract

Objective: To prepare dl-tetrahydropalmatine flexible liposomes and study its transdermal absorption effect. Method: The flexible liposomes was prepared by film dispersion method

modified Franz diffusion cell method was used to study its transdermal absorption effect. Result: Particle size of the flexible liposomes was (112.3±59.2) nm with a normal distribution basically

entrapment efficiency was 82.7%.Cumulative permeation amount of dl-tetrahydropalmatine flexible liposomes was 2 121 μg within 12 h

which was significantly higher than that of tincture (1 153 μg).The retention rate in skin was 53.9%

which was obviously higher than that of tincture(11.2%). Conclusion: Transdermal absorption effect of these prepared dl-tetrahydropalmatine flexible liposomes was superior than that of tincture.

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