SUN Dan-dan, XU Xin-gang, SHENG Li-song, et al. Optimization of Self-microemulsion Drug Delivery System of Ursolic Acid by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 46-50.
SUN Dan-dan, XU Xin-gang, SHENG Li-song, et al. Optimization of Self-microemulsion Drug Delivery System of Ursolic Acid by Central Composite Design/Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 46-50. DOI: 10.11653/syfj2013080046.
Objective: To optimize formulation of ursolic acid self-microemulsion drug delivery system using central composite design/response surface methodology. Method: With ratio of surfactants and cosurfactants and oil content as independent variables
particle size and saturated drug doading were taken as dependent variables
optimum formulation was screened by SAS9.1.3 software
and verified. Result: Optimized formulation of ursolic acid self-microemulsion was oil phase(MCT)-emulsifier(HS15)-cosurfactants(alcohol) 12.5:62.5:25. Conclusion: This optimized formulation of ursolic acid self-microemulsion drug delivery system could be obtained exactly and conveniently by central composite design response surface methodology
and established model had a reliable predictability.