穿心莲内酯自微乳化制剂的处方优化及质量评价

朱双燕; 尹蓉莉; 崔名全; 孔艳; 张立; 陈柳钦

doi:10.11653/syfj2013080055

您当前的位置：

首页 >

文章列表页 >

穿心莲内酯自微乳化制剂的处方优化及质量评价

更新时间：2024-01-04

- 穿心莲内酯自微乳化制剂的处方优化及质量评价
- Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation
- 中国实验方剂学杂志 2013年19卷第8期页码：55-59
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013080055
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
朱双燕, 尹蓉莉, 崔名全, 等. 穿心莲内酯自微乳化制剂的处方优化及质量评价[J]. 中国实验方剂学杂志, 2013,19(8):55-59.

ZHU Shuang-yan, YIN Rong-li, CUI Ming-quan, et al. Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 55-59.
朱双燕, 尹蓉莉, 崔名全, 等. 穿心莲内酯自微乳化制剂的处方优化及质量评价[J]. 中国实验方剂学杂志, 2013,19(8):55-59. DOI： 10.11653/syfj2013080055.

ZHU Shuang-yan, YIN Rong-li, CUI Ming-quan, et al. Prescription Optimization and Quality Evaluation of Andrographolide Self-microemulsion Preparation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(8): 55-59. DOI： 10.11653/syfj2013080055.

摘要

目的: 优选穿心莲内酯自微乳化制剂的处方工艺

并对其质量进行评价。方法: 通过溶解度试验、处方配伍对比试验及绘制三元相图优选处方辅料种类和用量范围

以形成乳液的形态、粒径、自乳化时间、制剂稳定性及zeta电位为指标

采用星点设计-效应面优化法优化自微乳化处方

并评价其质量。结果: 穿心莲内酯自微乳化最佳处方为m聚山梨酯-80:m油酸乙酯:m甘油=50:26:26

乳滴粒径39.5 nm

Zeta电位-15.18 mV

自乳化时间40.53 s。结论: 所制备的穿心莲内酯自微乳化制剂澄清透明

物理稳定性良好。

Abstract

Objective: To optimize formulation of andrographolide self-microemulsifying preparation and evaluate its quality. Method: Type and dosage range of excipients was selected by solubility test

prescription compatibility comparison test and drawing ternary phase diagram

with appearance

particle size

zeta potential

self-emulsifying time and preparation stability of the formed emulsion as indexes

central composite design-response surface methodology was used to optimize self-microemulsion prescription and evaluate its quality. Result: Optimum prescription of this preparation was as following:mtween-80:methyl oleate:mglycerol=50:26:26

particle size 39.5 nm

zeta potential -15.18 mV

self-emulsifying time 40.53 s. Conclusion: These acquired androgra-pholide self-microemulsion preparation was clear and transparent with good physical stability.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

穿心莲内酯药理作用及机制研究进展

星点设计-效应面法优化枸杞多糖含片的处方并考察其免疫调节作用

共载多西他赛和藤黄酸白蛋白纳米粒的处方优选和质量评价

星点设计-效应面法优化阴道用儿黄散白及胶缓释双层膜的处方

神经生长因子温敏凝胶对大鼠坐骨神经损伤的修复作用