Objective: To establish a quick method for the determination of 27 pesticide multi-residues in Angelica Pubescentis Radix by using QuEChERS and online gel permeation chromatography-gas chromatography/mass spectrometry (GPC-GC-MS). Method: Pesticides were extracted from samples with 1% acetic acid in acetonitrile under ultrasonic operation and cleaned up by dispersive solid phase extraction

and then analyzed by using online GPC-GC-MS in selective ion monitoring mode (SIM). Result: Twenty-seven kinds of pesticides showed good linearity in a detected concentration range with good correlation coefficient (r=0.994 3-0.999 9). The limits of detection and limits of quantization ranged from 0.037 5 to 3.040 0 μg·L-1 and 0.125 0 to 10.100 0 μg·L-1. The recoveries were 61.7%-114% and the relative standard deviations were 1.03%-13.9% at the spiked level of 0.1 mg·kg-1. Conclusion: This method is simple

rapid

selective and accurate

meet the requirement of pesticide multi-residues analysis. It can detect 27 pesticide multi-residues in Angelica Pubescentis Radix.