Objective: To study the effect of Panax notoginseng saponins(PNS) on the inflammatory factors and microglia cell of senescence-accelerated mouse prone 8 (SAMP8) mice. Method: SAMP8 mice were randomly divided into four groups: PNS high-dosage group

PNS low-dosage group

huperzine A group and model control group. The high-dosage group and low-dosage group were treated with 200

100 mg·kg-1 PNS respectively per day and the huperzine A group was treated with 0.3 mg·kg-1 huperzine A by intragastric administration

per day for 8 consecutive weeks.The serum cytokines of SAMP8 like interleukin(IL)-1β

IL-6

tumor necrosis factor-α(TNF-α)

complement 1q(C1q) were measured by ELISA. The morphological changes of microglia cells were observed by light microscopy with HE staining. Result: The level of IL-1β in the high-dose group was lower than that in the model group (P<0.05)

and compared to the model group

the content of IL-6 in PNS high

low-dose groups showed significantly different(P<0.05). The level of C1q in the blank group was higher than that in the high-dose group and positive group. HE staining showed that microglia in the hippocampus of the model group was over-activation

and swallowed nerve cells

while the microglia in the treatment groups was not activated. Conclusion: PNS can reduce the inflammatory response in SAMP8 mice.