Objective: To study the character of hyperlipidemia concurrent cerebral ischemia and analyze the influence of hyperlipidemia inflammation factor on cerebral ischemia by comparing inflammation change in different time change between hyperlipidemia and cerebral ischemia model and normal rat. Method: Dividing experimental rats into normal control

normal sham operation group

day 3

day 7 after normal ischemia and hyperlipid

sham operation group

day 3

day 7 after ischemia with hyperlipidemia. Based on time is day 3 or day 7 after cerebral ischemia. Building classic hyperlipidemia rat model with high fat diet

to confirm a successful model and detect the concentration of serum lipid.Constructing middle cerebral artery occlusion model

and observe the brain ischemia injury of rat. Detect the concentration of monocyte chemotactic protein-1(MCP-1)

tumor necrosis factor(TNF-α)

creactive protein(CRP) and superoxide dismutase(SOD) in serum between groups by ELISA. Result: The concentration of MCP-1

TNF-α and CRP were increased in day 3 and day 7 after cerebral ischemia model. Compared to normal cerebral ischemia group

in hyperlipidemia concurrent cerebral ischemia group

the concentration of MCP-1

TNF-α were higher with significant difference in day 3 and in day 7 after ischemia (P<0.05). The concentration of CRP were higher with significant difference in day 3 and were prominently decreased in day 7 after ischemia (P<0.05). The concentration of SOD was prominently decreased in the serum after cerebral ischemia in hyperlipidemia and normal groups

compared to sham operation groups and hyperlipidemia sham operation groups. SOD was prominently decreased in day 3 hyperlipidemia concurrent cerebral ischemia (P<0.05). Conclusion: Under the condition of hyperlipidemia

the inflammatory factors have not only accumulated phenomenon

but also specific expression in the difference of cerebral ischemia period

which is contributed to the recovery of the lesion in recovery phase.