Objective: To observe effects of ethanol extraction from Cassiae Semen on leptin and neuropeptide Y(NPY) in hyperlipidemia rats. Method: The rat hyperlipidemia model was established by feeding high calorie-diet. After modeling

the selected rats were randomly divided into six groups: normal control group

model group

positive control group

low dose group

medium dose group and high dose group. Positive control group was administrated Xuezhikang capsule at dose of 0.15 g·kg-1. Low dose group

medium dose group and high dose group were administrated at different concentrations of ethanol extraction of Cassiae Semen

which was respectively 4

8

16 g·kg-1. All groups were applied by intragastric administration for 4 weeks. Except normal control group

the remains were fed with high calorie-diet. After the last administration

the serum content of total cholesterol (TC)

triglyceride(TG)

low-density lipoprotein-cholesterol(LDL-C)

high-density lipoprotein-cholesterol(HDL-C) and glucose(Glu) were detected by automated chemistry analyzer. And the content of leptin and NPY was determined by ELISA. Result: The content of TC

TG

LDL-C and Glu was decreased

and the content of HDL-C was increased in medium dose group and high dose group of ethanol extraction of Cassiae Semen

compared with model group(P<0.01). At the same time

the content of leptin and NPY was decreased in medium dose group and high dose group(P<0.01). Conclusion: Ethanol extraction of Cassiae Semen can regulate the metabolic process of blood lipids and blood glucose levels of hyperlipidemia model rats

which might be contributed to its effect on leptin-hypothalamic neuropeptide Y chain.