Objective: To observe the effects of Xiaochaihu decoction on vasoactive intestinal peptide(VIP)

gastric emptying and small intestine advance rate in functional dyspepsia (FD) rats. Method: 48 rats were randomly divided into four groups: blank group

model group

Xiaochaihu decoction group and domperidone group

each group had 12 rats. FD models were established by chronic restraint stress and excessive fatigue and irregular feeding

once per day for continuous 3 weeks. Then feed the rats in different groups with normal saline

normal saline

Xiaochaihu decoction and Domperidone liquor respectively by intragastric administration for continuous 14 days. After 14 days intragastric administration

VIP of each rat was detected. Gastric emptying and small intestine advance rate of each rat were tested. Result: Compared to the blank group

gastrointestinal Hormone VIP and gastric residue obviously increased while small intestine advance rate significantly decreased in model group (P<0.05 or P<0.01). Compared to the model group

gastrointestinal hormone VIP and gastric residue obviously decreased while small intestine advance rate significantly increased in the Xiaochaihu decoction and domperidone group (P<0.05 or P<0.01). Conclusion: Xiaochaihu decoction can reduce gastrointestinal hormone VIP

advance gastric emptying and small intestine advance rate in functional dyspepsia rats.