Objective: Observe the pulmonary vascular pathological change in chronic obstructive pulmonary disease(COPD) rat models of application for activating blood circulation and eliminating stasis drugs

explore the vascular remodeling of COPD. Method: Make COPD models by droping lipopolysaccharide (LPS) into tracheal and passive smoking method. From 29th to 42th days

group H are gave intraperitoneal injection of Chuanqing solution 8 mL·kg-1·day-1; group C are gave volumetric saline. Execute the three groups rats in sixth weeks

observe the pathological changes of pulmonary vessels in rat models applied activating blood circulation and eliminating stasis drugs. Result: Compared to group N there are characteristically changes in group C and H

but different in degree. Compared to group N and C

vascular smooth muscle cells of group H have mild hyperplasia

the wall was thickened slightly

the ratio of blood vessel wall/blood vessel wall and hemal wall area/vascular area are significantly (P<0.01).Under the electron microscopy observation

the endothelial cells

the basement membrane

mitochondria and shelf small body of group N are normal; group C appear obvious changes. The pinocytotic vesicles of endothelial cells increased

mitochondrion edema or vacuoles degenerate. The nuclei have become obvious tendency of becoming pyknotic. Many nucleation white blood cells are blocked in the capillary lumen; endothelial cells

the basement membrane

mitochondria and lamellar body in group H are basically normal. There are a few nucleation white blood cells in the capillary lumens. Conclusion: Traditional Chinese medicine for activating blood circulation and eliminating stasis can slow or improve the blood vessels remodeling of COPD. It guides the treat should accord to its different stages in the process of development and combined with illness

use the drugs for activating blood circulation and eliminating stasis flexibly

give a scientific understanding of the importance in control of COPD to improve the clinical effect.