Objective: To study the therapeutic action and mechanism of total flavonoids of Clerodendranthus spicatus (TFC) on rats models of chronic abacterial prostatitis. Method: Sixty healthy adult male SD rats were randomly divided into six groups

10 rats in each group: blank control group

model group

positive control group (250 mg·kg-1·d-1)

TFC low-dose

middle-dose and high-dose group (100

200

400 mg·kg-1)

respectively. Except for normal group

the rats models of Chronic abacterial prostatitis were builded by subcutaneous injection of oestradiol monobenzoate at the dose of 0.25 mg·kg-1 after castration

and then treated with TFC at 100

200

400 mg·kg-1 by oral administration whileblank and model group were given normal saline

once a day for 30 days. White blood cell(WBC) count

lecithin corpuscle density and prostate index in prostatic fluid were examined

and the expressions of tumor necrosis factor(TNF-α) and interleukin-8(IL-8) in the serum and prostate tissues of the rats were detected by ELISA. Result: Compared with model group

WBC count and prostate index were reduced and lecithin corpuscle density were increased in prostatic fluid by TFC

which showed significant statistical differences(P<0.01 or P<0.05)

and the levels of TNF-α and IL-8 in the serum and prostate tissues of the rats were reduced. Conclusion: TFC has therapeutic effects on chronic abacterial prostatitis inrats models

and the mechanism may be related to decreasing the levels of TNF-α and IL-8 in the serum and prostate tissues.