Objective: To observe the effect of salvia miltiorrhiza and ligustrazine injection in combination with traditional Chinese medicine enema on chronic kidney disease (CKD)

endothelin (ET)

6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B2 (TXB2). Method: Seventy patients with stage 3-4 CKD were randomly divided into observation group and control group (n=35 each). Control group was received western medicine therapy and rhubarb fluid enema. 200 mL rhubarb fluid were given via retention enema for 1-2 h and inserted into the intestine 20cm daily. The patients in observation group

on the basis of control group

were received salvia miltiorrhiza and ligustrazine injection 15 mL

diluted with 100 mL saline

iv

for 10 days. After two days' rest

the patients were received another course. There were two courses. Serum creatine (SCr)

blood urea nitrogen (BUN)

ET

6-Keto-PGF1α and TXB2 were tested before and after treatment. Result: The total effective rate of observation group (71.43%) was higher than control group (45.71%) with a significant difference (P<0.05). BUN and SCr in observation group were lower than control group (P<0.05

P<0.01); After treatment

ET and TXB2 were decreased

and 6-keto-PGF1α increased in two growps. ET and TXB2 in observation group were lower than those in control group

however

6-keto-PGF1α in observation group was higher than that in control group (P<0.05). Conclusion: Salvia miltiorrhiza and ligustrazine injection can decrease BUN and SCr in patients with stage 3-4 CKD

improve clinical efficacy

ameliorate hypercoagulative state and protect vascular endothelial function.