Objective: To observe the efficacy of Chinese herbal medicine on constipation induced by diabetes according to differentiation of syndrome and its effect on blood glucose and glycosylated hemoglobin. Method: One hundred and twenty cases of constipation induced by diabetes randomly divided into two groups with 60 patients in each group. The treatment group was treated with Chinese herbal medicine decoction based on the routine treatment while the control group was treated with mosapride and Vitamin B12 for 14 days. Stool

blood glucose and glycosylated hemoglobin before and after treatment were investigated. Result: The total effective rate of constipation was 93.5% in the treatment group

but only 74.2% in the control group (P<0.01). The blood sugar level before and after meal and glycosylated hemoglobin in the two groups were decreased. Treatment group was significantly better compared with the control group (P<0.05). Conclusion: Chinese herbal medicine based on syndrome differentiation shows positive effect on releasing constipation induced by diabetes

and helps to improve blood glucose.