Objective: To optimize formation technology of compound Lujiao granules. Method: With hygroscopicity

formability

mobility

dissolubility and appearance as comprehensive index

kinds and ratio of excipients were selected by single factor test;With forming rate as index

L9(34) orthogonal test was used to investigate effects of horizontal speed

roller speed and pre-pressure on dry granulation process. Result: Optimum ratio of prescription was extract powder-dextrin-lactose-colloidal silicon dioxide 84.5%: 12%: 3%: 0.5%;The best technology parameters were as follows:vertical speed 10 r·min-1

horizontal speed at 30 r·min-1

roller speed 4 r·min-1

pre-pressure 6 MPa. Conclusion: These prepared granules had good formability

good anti-wet performance

high solubility and color uniformity;This optimized formation technology was simple

feasible and suit to industrial production.