Objective: To study inhibitory activity of raw products and five processed products of Psoralea corylifolia for α-glucosidase. Method: With acarbose as positive control

inhibitory activity was screened by α-glucosidase in vitro inhibitory model. Result: Each parts from raw and processed products of P. corylifolia had some α-glucosidase inhibitory activity

and the activity of them were higher than acarbose.Methanol total extracts of salt steamed P. corylifolia

fried salt P. corylifolia and fried P. corylifolia showed higher inhibitory activity (IC50=23.03

31.26

36.06 μg·L-1

respectively) than methanol total extract of raw P. corylifolia (IC50=46.47 μg·L-1). Petroleum ether extracts of salt steamed P. corylifolia and tripterygium wilfordii method P. corylifolia had higher inhibitory activity (IC50=17.96

34.02 μg·L-1

respectively) than petroleum ether extracts of raw P. corylifolia (IC50=46.94 μg·L-1).Acetic ether extracts of five processed products (salt steamed P. corylifolia

tripterygium wilfordii method P. corylifolia

fried salt P. corylifolia

fried P. corylifolia ang wine fried P. corylifolia) had higher inhibitory activity (IC50=51.27

39.08

40.86

45.54

36.06 μg·L-1

respectively) than acetic ether extracts of raw P. corylifolia (IC50=71.28 μg·L-1).n-Butyl alcohol extacts of salt steamed P. corylifolia and wine fried P. corylifolia showed higher inhibitory activity (IC50=47.52

36.06 μg·L-1

respectively) than n-butyl alcohol extacts of raw P. corylifolia (IC50=51.27 μg·L-1). In addition

the inhibitory activity of each parts extracts was positively correlated with the mass concentration

that was in a concentration dependent manner. Conclusion: Raw products and five processed products of P. corylifolia exhibited certain α-glucosidase inhibitory activity.