鸦胆子油自微乳的制备及溶出度考察

蒋楠; 李晔; 陈钢; 邵阿丽; 孙雯; 李彤晖; 辛永洁; 李丹

doi:10.11653/syfj2013090045

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鸦胆子油自微乳的制备及溶出度考察

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- 鸦胆子油自微乳的制备及溶出度考察
- Preparation and Dissolution Investigation of Oil Self-microemulsion
- 中国实验方剂学杂志 2013年19卷第9期页码：45-48
- 作者机构：
- 作者简介：
- 基金信息：
  
  陕西省"13115"科技创新工程重大科技专项项目(2009ZDKG-82)
- DOI：10.11653/syfj2013090045
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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蒋楠, 李晔, 陈钢, 等. 鸦胆子油自微乳的制备及溶出度考察[J]. 中国实验方剂学杂志, 2013,19(9):45-48.

JIANG Nan, LI Ye, CHEN Gang, et al. Preparation and Dissolution Investigation of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48.
蒋楠, 李晔, 陈钢, 等. 鸦胆子油自微乳的制备及溶出度考察[J]. 中国实验方剂学杂志, 2013,19(9):45-48. DOI： 10.11653/syfj2013090045.

JIANG Nan, LI Ye, CHEN Gang, et al. Preparation and Dissolution Investigation of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48. DOI： 10.11653/syfj2013090045.

摘要

目的: 制备鸦胆子油自微乳

并考察其溶出度。方法: 通过溶解度试验、气相色谱法筛选辅料

伪三元相图优化自微乳处方

并进行药物溶出度试验。结果: 鸦胆子油自微乳最优处方为鸦胆子油-辛酸癸酸三甘油酯-聚氧乙烯氢化蓖麻油-聚乙二醇400 12:12:65:11

乳滴粒径<50 nm

15~20 min可基本完全溶出。结论: 鸦胆子油自微乳稳定性良好

提高了用药的顺应性

且制备工艺简单。

Abstract

Objective: To prepare Brucea javanica oil self-microemulsion

and investigate its dissolution. Method: Solubility test and gas chromatography were used to select adjuvants

pseudo-ternary phase diagram was used to optmize prescription of the self-microemulsion

and dissolution test of the self-microemulsion was adopted. Result: Optimum prescription of B. javanica oil self-microemulsion was B. javanica oil-caprylic capric triglyceride-polyoxyethylene hydrogenated castor oil-polyethylene glycol 400 12%: 12%: 65%: 11%

particle size of it was<50 nm and it could be completely dissolved in 15-20 minutes. Conclusion: B. javanica oil self-microemulsion had good stability

it improved medication compliance

and this preparation technology was simple and stable.

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