Objective: To observe the effects of Shengqing Jiangzhuo Fang(SQJZF) on skeletal muscle in monosodium L-glutamate(MSG) obese rats with insulin resistance. Method: The rat MSG-obese model was produced by giving neonatal rats subcutaneous injection of monosodium glutamate and induced with high-fat diet. Sixty MSG rats were divided into seven grous(4 male and 4 female per gtoup) randomly.the rosiglitazone group

the fenofibrate group

high dose

middle dose and low dose of SQJZF.After the administration for 50 days

levels of cholesterol (TC)

triglyceride (TG)

low density lipoprotein cholesterin(LDL-C)

high density lipoprotein cholesterin(HDL-C) and glucogn in muscle tissue were measured. Result: SQJZF showed good effects on the animal models. Compared with the model group

treatment with SQJZF at a dose of 6

3

1.5 g·kg-1 for 50 d decreased levels of TC

TG

LDL-C and glucogn in muscle tissue (P<0.01);levels of HDL-C was significantly elvated by treatment with SQJZF at a dose of 3 g·kg-1(P<0.01). Conclusion: SQJZF may contribute to ameliorate the glucolipid metablization in diabetic skeletal muscle.