Objective: To study effect of different technologic extracts from shengzhi Yingyang fang on renal function poisoned by adenine in mice. Method: One hundred SPF grade male healthy mice were randomly divided into 5 groups

which were the control group

the model group

Shengzhi Yingyang Fang 1 group(water extraction)

Shengzhi Yingyang Fang 2 group(75% alcohol)

Shengzhi Yingyang Fang 3 group(40% alcohol). The models were established by orally giving adenine to the mice at 300 mg·kg-1 and at the same time

3 experimental groups were orally given different technologic extracts from sheng zhiyingyang fang decoctum (crude drugs at 1.96 g·kg-1)

five times a week for 2 months. Result: Shengzhi Yingyang fang significantly decreased (P<0.05)the contents of creatinine (SCr)

urea nitrogen(BUN)

lactic acid(LD) and the activity of xanthine oxidase(XOD)in plasma. Furthermore

it could significantly reduce(P<0.05) the activities of acid phosphatase (ACP) and alkaline phosphatase (AKP) and improve(P<0.05)the activities of succinodehydrogenase (SDH) of renal tissue poisoned by adenine in mice. The effect of water extraction is the best. Conclusion: Different technologic extracts from shengzhi Yingyang fang decoctum have protective effects on renal function poisoned by adenine

among which the effect of water extract is the best.