菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响

郭爱民; 曹建民; 朱静; 周海涛

doi:10.11653/syfj2013090274

您当前的位置：

首页 >

文章列表页 >

菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响

更新时间：2024-09-23

- 菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响
- Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats
- 中国实验方剂学杂志 2013年19卷第9期页码：274-277
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013090274
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
郭爱民, 曹建民, 朱静, 等. 菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响[J]. 中国实验方剂学杂志, 2013,19(9):274-277.

GUO Ai-min, CAO Jian-min, ZHU Jing, et al. Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277.
郭爱民, 曹建民, 朱静, 等. 菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响[J]. 中国实验方剂学杂志, 2013,19(9):274-277. DOI： 10.11653/syfj2013090274.

GUO Ai-min, CAO Jian-min, ZHU Jing, et al. Effects of on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277. DOI： 10.11653/syfj2013090274.

摘要

目的: 研究菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响。方法: 以大强度耐力训练大鼠为模型

65只42 d龄雄性Wistar大鼠为对象

随机分为5组:静止对照组、运动对照组、运动+低剂量菟丝子组、运动+中剂量菟丝子组、运动+高剂量菟丝子组

每组12只。采用专业灌胃器每天灌胃给药(ig)1次。低、中、高剂量组ig剂量分别为1.16

2.32

6.96 g·kg-1·d-1

ig体积为5 mL·kg-1。静止对照组和运动对照组ig等量生理盐水。6周力竭游泳训练。末次训练后24 h

测定体重、力竭游泳时间及脑组织中超氧化物歧化酶(SOD)等与疲劳作用相关的指标。结果: 运动+菟丝子各剂量组体重均大于运动对照组(P<0.05)

力竭游泳时间均长于运动对照组(P<0.01)。力竭游泳导致大鼠脑组织中MDA含量显著升高。运动对照组及运动+菟丝子各组分别升高至(6.46±0.21)

(5.17±0.26)

(4.89±0.19)

(4.76±0.33)μmol·L

但运动+菟丝子各组明显低于运动对照组(P<0.01)。SOD

GSH-Px活性显著下降。运动对照组及运动+菟丝子各组SOD分别下降至(207.35±12.27)

(245.85±11.31)

(253.98±11.24)

(261.31±12.69)U·mL-1

GSH-Px分别下降至(52.24±5.35)

(68.57±5.83)

(71.96±5.96)

(73.38±5.15)U·mg-1

但运动+菟丝子各剂量组明显高于运动对照组(P<0.01)。结论: 菟丝子具有提高脑组织抗氧化酶活性的作用

从而抑制大强度力竭运动造成的脑组织氧化损伤

延缓疲劳发生。

Abstract

Objective: To study the effects of Cuscuta chinensis on free radical in brain tissue and ability of resistance in exercise-induced fatigue rats. Method: The high-intensity endurance training in rats was used to establish exercise-induced fatigue model.The modeling rats were divided into the 4 groups:model group

low

medium and high groups of C. chinensis group (1.16

2.32

6.96 g·kg-1·d-1

ig). Another group without exercise as a control group was set after 6 weeks of exhaustive swimming training. 24 h after the last training

weight

exhaustive swimming time and malondialdehyde(MDA)

superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in brain were observed. Result: The weight in C. chinensis groups was increased group(P<0.05)

swimming time became longer (P<0.01) compared with model.In C. chinensis groups MDA were decreased compared with model group (P<0.01)

and SOD

GSH-Px activity was significantly increasee. Conclusion: C. chinensis has the antioxidation action and increase ability of resistance on exercise-induced fatigue

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响

五味子根、茎、叶、果多糖对D-半乳糖致衰老小鼠运动耐力的影响

红参和红景天配伍前后主要成分及抗疲劳活性的变化

飓风Ⅰ号、Ⅱ号口服液对提高小鼠运动能力作用的研究

康脑灵胶囊治疗血管性痴呆的实验研究