Objective: To observe effect of astragalosides extract on liver fibrosis in rats. Method: Sixty SD rats were randomly divided into six groups: normal control group (A)

model group (B)

colchicine group(C)

low-dose astragalosides group(D)

middle-dose astragalosides group (E) and high-dose astragalosides group (F).Liver fibrosis model in rat was produced with bovine serum albumin(ABS). Group C received colchicine (0.1 mg·kg-1·d-1);group D

E

F received low-dose astragalosides (15 mg·kg-1·d-1)

middle-dose astragalosides (30 mg·kg-1·d-1) and high-dose astragalosides (60 mg·kg-1·d-1) ig respectively. After 55 days

serum levels of serum total protein (TP)

albumin(ALB)

alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

hyaluronic acid(HA)

laminin(LN)

type Ⅲ procollagen(PC-Ⅲ) and type Ⅳ collagen (Ⅳ-C) in different groups were detected. Result: Compared with model group

levels of ALT

AST

HA

LN

PC-Ⅲand Ⅳ-C in the treatment groups were obviously improved.It had significantly statistical difference(P<0.05

P<0.01).Pathological result showed that the liver fibrosis in the treatment groups was signiflcantly attanuated. Conclusion: These results suggested that astragalosides shows obvious effect against rat hepatic fibrosis.