Objective: To observe the effect of Shenxiong Huayu capsule preconditioning on the expression of vascular endothelial growth factor(VEGF) after cerebral ischemia reperfusion injury in rats

to investigate the protective effect of shenxiong Huayu capsule on acute cerebral ischemia reperfusion injury in rats. Method: The rats were randomly divided into five groups:sham operatiion group

ischemia reperfusion group

Shenxiong Huayu capsule high

medium

low dose preconditioning group(480

240

120 mg·kg-1). The group were divided randomly into 3

6

12

24

48

72 h group after the 2 hour focal cerebral ischemia reperfusion(n=6). Intragastric administration 7 day

once a day. Middle cerebral artery occlusion (MCAO) and reperfushion model was made by an intraluminal filament method. The expressions of VEGF proteins were detected by using immunohistochemical method

the neurological deficit score was assessed at the same time. Result: Compared with the sham operation group

severe neurologic deficits of rats were presented and increases of VEGF in the ischemia reperfusion group at every time point(3

6

12

24

48

72 h)

and showing a significant difference(P<0.05

or P<0.01). Compared with the ischemia reperfusion group

neurologic deficits of rats were relieved significantly and VEGF expression increased distinctly in Shenxiong Huayu capsule dose preconditioning group at every time point(3

6

12

24

48

72 h)

showing a significant difference(P<0.05

or P<0.01)

high dose group showing best significant. Conclusion: Shenxiong Huayu Capsule may relive acute cerebral ischemia reperfusion injury in rats by increasing VEGF expression.