Objective: To investigate the efficacy of ganglioside supplemented by Danshen injection in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Method: Seventy neonates with HIE were randomly divided into observation group and the control group

the control group were given symptomatic and supportive treatment

the observation group was received ganglioside and Danshen injection. The efficacy

neonatal behavioral neurological assessment(NBNA) scores changes and the improvement of convulsions

disturbance of consciousness

abnormal primitive reflexes and dystonia were observed and compared. Result: The effective rate of the observation group was 94.29%

significantly higher than that of the control group (77.14%)

the difference had statistically significant (P<0.05). After one week and two weeks of treatment

the NBNA scores of two groups were significantly improved compared with before treatment

there were statistically significant (P<0.05). Compared with the control group

NBNA scores in the observation group after treatment were improved significantly (P<0.05). The time of convulsions

disturbance of consciousness

the original abnormal reflexes and dystonia were improved in the observation group significantly compared with those of the control group (P<0.05). Conclusion: Ganglioside supplemented by Danshen injection is effective in the treatment of HIE

and shows marked clinical value.