Objective: To optimize preparation technology of blank pellets core with different pharmaceutical excipients

and explore the suitability between process conditions of pellets core and raw materials of preparation. Method: Blank pellets core of microcrystalline cellulose

starch

dextrin and lactose were prepared by centrifugal granulation

with yield of pellets core between 0.25-0.355 nm of particle size as main index

single factor test

uniform design test and multiple linear regression analysis method were used to optimize preparation process conditions of blank pellets core of this four kinds of pharmaceutical excipients

and comparison and difference analysis were made after optimization. Result: The appropriate process parameters of these four pharmaceutical excipients blank pellets core were as follows:water as adhesive of microcrystalline cellulose blank pellets core

and 50%-60% sucrose solution as that of other blank pellets core of three excipients

the jet velocity between 12-16 r·min-1

the bost rotating speed of blank pellets core with microcrystalline cellulose

dextrin and lactose 225 r·min-1

and that of blank pellets core with starch 275 r·min-1

the jet pressure between 0.025-0.05 MPa

the temperature at 25 ℃

the slit air flow chose minimum or medium. Conclusion: There was generally appropriate ranges of process parameters of these four different excipients blank pellets core prepared by centrifugal granulation

it could provide references in screening prescription and optimizing process parameters of drug pellets prepared by centrifugal granulation method.