Objective: To investigate effects of different aperture ultrafiltration membranes on removal technology of pyrogen for geniposide. Method: Effect of removal process of pyrogen in geniposide with different aperture ultrafiltration membranes was investigated

kinetic turbidimetric limulus reagent method was adopted to quantitative determine the content of endotoxin in raw material of geniposide before and after ultrafiltration

in order to screen the best removal process of pyrogen in geniposide. Result: The 100 kDa aperture ultrafiltration membrane could be better remove pyrogen in geniposide liquid

and it had little influence on geniposide. Conclusion: Ultrafiltration method could be used to remove pyrogen in geniposide

this result could provide reference for removing pyrogen in other traditional Chinese medicine injections and raw material production processes.