Objective: To study the influence of Kanli granule on myocardial energy metabolism and cardiac function. Method: Heart failure model were developed in rats by transverse aortic constriction(TAC). After 1 week of the operation

rats were treated orally with trimetazidine(0.36 mg·kg-1)

perindopril(5.4 mg·kg-1)

Kanli granule high-medium-low dose(13.5

6.75

3.38 mg·kg-1). After 32 weeks

myocardial energy metabolism and hemodynamic were examined. Result: Compared with group sham

LVSP(P<0.01) and LVEDP(P<0.05) was increased in model group

＋dp/dtmax(P<0.01) and －dp/dtmax(P<0.05) was large in group BD

ATP

ATP/ADP was reduced (P<0.001) in model group BD;Compared with model group

LVEDP(P<0.05) were all reduced in group of Kainli granule

＋dp/dtmax(P<0.05)

ATP was increased(P<0.05) in group M of Kainli granule. Conclusion: Kanli granule can improve left ventricular diastolic function

energy metabolism and improve the efficacy of cardiac structure and function.