Objective: To study the compatibility of the Suoquan pill based on excretion of urine. Method: The combinations including Alpiniae Oxyphyllae Fructus

Linderae Radix

Dioscoreae Rhizoma

Alpiniae Oxyphyllae Fructus+Linderae Radix

Alpiniae Oxyphyllae Fructus+Dioscoreae Rhizoma

Linderae Radix+Dioscoreae Rhizoma

Linderae Radix+Dioscoreae Rhizoma and Suoquan pill.Treated respectively with the combination of herbs and D-gal

seted up normal group at the same time.To assess the bladder function by urodynamics and measure the aquaporin 2(AQP2)

aldosterone (ALD)

antidiuretic hormone (ADH) associated with the urine formation by ELISA technology. Result: Compared with the normal group

model group AQP2

ADH

ALD content significantly reduced (P<0.01)

Bladder Leak Point Pressures(BLPP)

abdomen leak point pressure(ALPP)

maximum voiding pressure(MVP)significantly reduced (P<0.01)

also

and the bladder compliance(BC)elevated (P<0.01).Among separated recipes groups

Suoquan pill was better than other groups.Alpiniae Oxyphyllae Fructus has strongest efficacy of single herb;Linderae Radix was significant effects in the urine formation

combination of Alpiniae Oxyphyllae Fructus has better efficacy. Dioscoreae Rhizoma plays an important part in ameliorating the senescent bladder function

combination of Linderae Radix has better efficacy in all we check. Conclusion: The result is conformed to the theory of traditional Chinese medicine.