Objective: To compare the effects of Yinchenhao Tang water extract and its alcohol extract on rat liver injury model and explore the possible reasons for differences in efficacy. Method: The differences were compared in composition of the two extracts by TLC and determining the content of geniposide and emodin by HPLC. The liver injury model was established with galactosamine

the rats were randomized into natural group

model group

Yinchenhao Tang water extract of high dose group

Yinchenhao Tang water extract of low dose group

Yinchenhao Tang alcohol extract of high dose group

Yinchenhao Tang alcohol extract of low dose group. Rats in medication groups were administrated ig with corresponding herbs

water extract group(1.67

0.84 g·kg-1)

alcohol extract group(1.67

0.84 g·kg-1)and natural group was given normal diet.After treatment for 8 days

the influence of the treatments on the serum hepatic injury indicators was investigated.Hepatic tissues were detected by HE. Result: There were differences between the compositions of two extracts

but both had the protection effect of liver injury with different intensity

and the level of aspartate aminotransferase(AST)

glutamic-pyruvic transaminase(ALT)

alkaline phosphatase(ALP)

triglycerides(TG)

total bilirubin(T-Bil)in liver of water extract group were significantly lower than those of model group(P<0.05

P<0.01).It can improve the steatosis of liver in rats. Meanwhile

the level of AST

ALT

ALP in serum of alcohol extract group were also significantly lower than those of model group(P<0.05

P<0.01).And the content of geniposide and emodin of water extract were lower than those of alcohol extract. Conclusion: Comparing with ethanol extracts of Yinchenhao Tang

its water extracts had certain advantage of the protective effect on D-galactosamine-induced liver injury in rats according to pharmacodynamics results.