Objective: To research the effect of Weiyangning pill on gastrointestinal motility. Method: The experimental animal were randomized into control

Weiyangning pill low

medium and high dose (0.395

0.79

1.58 g·kg-1) groups

Weikangning group (0.4 g·kg-1)

domperidone group (0.05 g·kg-1). Pigeon vomiting experiment was used to determine the incubation period of vomiting and vomiting frequency. Intestinal motility in rat

normal isolated rabbit intestinal and inhibition of spasm induced by acetylcholine in isolated rabbit intestinal were employed to determine the muscle tension of intestine before and after administration then calculating the inhibition rate. Result: Weiyangning pill could reduce the frequency of pigeon vomiting

inhibit the contraction of in vivo intestinal

inhibit the contraction of normal isolated rabbit intestinal and inhibit the spasm induced by acetylcholine in isolated rabbit intestinal. Conclusion: Weiyangning pill can inhibit the gastrointestinal motility in experimental animals.