Objective: To explore the changes in serum leptin level in the patients with h-type hypertension and to observe the efficacy of Enalapril and folic on the serum levels of leptin in patients with h-type hypertension. Method: Seventy-six patients with h-type hypertension were randomly divided into two groups: the enalapril maleate folic Acid tablet group (n=38) and the enalapril group (n=38)

and selected 40 healthy person as control group. Serum leptin

BP

and plasma Hcy and left ventricular mass index(LVMI) were analysed the first 24 hours after admission and 2 mouths after treatment. Result: Serum leptin in h-type hypertension patients[(15.83±3.75)μg·L-1] was significantly higher than that of the controls [(7.35±2.17)μg·L-1]; the serum leptin increased with the increase of degree of h-type hypertension(P<0.05); after 2 mouths' treatment

controlled blood pressure

and decreased serum leptin and LVMI were seen in both the enalapril maleate folic acid tablet group and the enalapril group

significane was found in enalapril maleate folic acid tablet group(P<0.05). Conclusion: The level of serum leptin is avaluable negative index to indicate the severity of heart failure. Enalapril with folic acid tablets has a better effect on lower the serum leptin and improve myocardial hypertrophy.