Objective: To study the effect of Shexiang Baoxin pills on patients with unstable angina pectoris of coronary heart disease and its influence for the oxidative stress. Method: Eighty-four patients with unstable angina pectoris of coronary heart disease were randomly divided into control group and observation group with 42 cases in each group

the two groups were both treated with basic treatment of conventional antithrombotics and plaque stabilization treatment

the control group were treated with only isosorbide mononitrate tablets

10 mg each time

tid

the observation group were treated with Shexiang Baoxin pills based on the treatment of control group

2 pills each time

tid. The course was 8 weeks. The patients with angina attack were treated with nitroglycerin tablets

0.5 mg each time. The serum superoxide dismutase(SOD)

malonaldehyde(MDA)

total antioxidant capacity(TAC) and lipid peroxide(LPO)before and after the treatment were detected

and the frequency of angina pectoris and dosage of nitroglycerin were recorded. Result: The total effective rate of observation group after the treatment was 95.24%

and it was higher than 80.95% of the control group(P<0.05)

while the frequency of angina pectoris and dosage of nitroglycerin were both lower than those of control group(P<0.05)

SOD and TAC of two groups after the treatment were higher than those before the treatment

the increasing of observation group was more obvious(P<0.01)

MDA and LPO of two groups after the treatment were lower than those before the treatment

the decreasing in observation group was more obvious(P<0.01). Conclusion: Shexiang Baoxin pills combined with western medicine for treating patients with unstable angina pectoris of coronary heart disease is good

and mechanism of action may be related to the regulation for oxidation and antioxidation balance of myocardial cells.