Objective: To prepare acetaminophen-sodium alginate-carbon nanotubes gels microsphere

and investigate its in vitro release properties. Method: With acetaminophen as a model drug

1-ethyl-3(3-dimethylamino-propyl) carbodiimide as a coupling agent

and surface properties were improved by sodium alginate in order to prepare acetaminophen-sodium alginate-carbon nanotubes gels microsphere.Surface morphology of modified acetaminophen-sodium alginate-carbon nanotubes gels microsphere was analysed by FTIR and characterized by scanning electron microscope

release mechanism of acetaminophen-sodium alginate-carbon nanotubes gels microsphere artificial intestinal fluid was investigated. Result: After modified

drug loadings and release amount in medium of acetaminophen-sodium alginate-carbon nanotubes gels microsphere decreased with increasing the content of carbon nanotubes in this gels microsphere

and this gels microsphere showed a long time of release and drug release completely in simulated intestinal fluid. Conclusion: Multi-walled carbon nanotubes could be used as a drug delivery carrier for sustained-release preparations.