Objective: To optimize preparation technology of Coptis total alkaloids gelatin microsphere. Method: Coptis total alkaloids gelatin microsphere was prepared by emulsified cross linking method

with composite score of encapsulation efficiency and drug loading as index

effects of the concentration of gelatin

the dosage of crosslinking agent

feeding dosage and ratio of oil phase-water phase on preparation technology was investigated by orthogonal design. Result: Optimal preparation technology was obtained with the concentrations of gelatin 12%

the dosage of Coptis total alkaloids 1.7%

ratio of water phase to oil phase 1:12

the dosage of crosslinking agent 15%.These drug loaded microsphere were spherical with smooth surface

encapsulation efficiency was 63.7%

drug loading was 6.50%. Conclusion: This optimized preparation technology was reliable and stable

the prepared microsphere had good quality.