Objective: To optimize alcohol extraction technology of Qingzhi Tongmai granules. Method: With total content of saikosaponin a

saikosaponin d

jujuboside A

spinosin and yield of dry extract as index

orthogonal design was taken for investigating effects of the concentration of alcohol

the amount of alcohol

extraction time and times on extraction technology. Result: Optimal extraction conditions were as followings:reflux extracted 3 times with 6 folds of 70% ethanol for 1.5 hours each time. Conclusion: This optimized technology was reasonable

stable

simple

and suitable for industrial production of Qingzhi Tongmai granules.