脱水穿心莲内酯自乳化制剂的制备及质量评价

陈柳钦; 崔名全; 尹蓉莉; 朱双燕; 张立; 李开

doi:10.11653/syfj2013110028

您当前的位置：

首页 >

文章列表页 >

脱水穿心莲内酯自乳化制剂的制备及质量评价

更新时间：2024-01-04

- 脱水穿心莲内酯自乳化制剂的制备及质量评价
- Preperation and Quality Evaluation of Dehydroandrographolide Self-emulsifying Formulation
- 中国实验方剂学杂志 2013年19卷第11期页码：28-31
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.11653/syfj2013110028
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
陈柳钦, 崔名全, 尹蓉莉, 等. 脱水穿心莲内酯自乳化制剂的制备及质量评价[J]. 中国实验方剂学杂志, 2013,19(11):28-31.

CHEN Liu-qin, CUI Ming-quan, YIN Rong-li, et al. Preperation and Quality Evaluation of Dehydroandrographolide Self-emulsifying Formulation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 28-31.
陈柳钦, 崔名全, 尹蓉莉, 等. 脱水穿心莲内酯自乳化制剂的制备及质量评价[J]. 中国实验方剂学杂志, 2013,19(11):28-31. DOI： 10.11653/syfj2013110028.

CHEN Liu-qin, CUI Ming-quan, YIN Rong-li, et al. Preperation and Quality Evaluation of Dehydroandrographolide Self-emulsifying Formulation[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 28-31. DOI： 10.11653/syfj2013110028.

摘要

目的: 制备脱水穿心莲内酯自乳化制剂

并对其质量进行评价。方法: 通过溶解度试验初步筛选处方辅料种类

以乳化效果、乳化平衡时间、乳剂粒径大小及分布为指标

采用正交试验确定辅料

并结合三元相图确定最佳处方

考察该制剂稀释后形成乳液的外观、粒径、Zeta电位及制剂稳定性。结果: 脱水穿心莲内酯自乳化最佳处方为m聚山梨酯-80:m中链甘油三酯:m甘油=50:20:30

粒径23.7 nm

Zeta电位-14.47 mV

自乳化速度快

室温放置3个月后稳定性良好。结论: 优选的制备工艺简单、乳化时间快、粒径小

制备的自乳化制剂澄清透明、质量稳定。

Abstract

Objective: To prepare dehydroandrographolide self-emulsifying formulation and evaluate its quality. Method: Types of prescription accessories were screened by solubility test;With emulsifying effect

emulsification equilibrium time

particle size and distribution of this emulsions

accessories were determined by orthogonal test

and optimum prescription was determined by combining with ternary phase diagrams.After diluted

appearance

particle size

Zeta potential and stability of this formulation were investigated. Result: Optimum prescription of dehydroandrographolide self-emulsifying formulation was as following:mtween-80: mMCT:mglycerin=50:20:30

particle size of 23.7 nm

Zeta potential of -14.47 mV.Self-emulsifying speed was rapid

and it had good stability at room temperature for 3 months. Conclusion: This optimized preparation technology was simple with fast emulsifying time and small particle size

prepared self-emulsifying formulation was clear and transparent with stable quality.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

青蒿素自乳化制剂的设计、优化及质量评价

基于蛋白质组学的缺血性心脏病气阴两虚证小鼠模型的建立与评价

AHP-CRITIC混合加权法、灰色关联度分析与反向传播人工神经网络在芪志方提取工艺优化中的综合应用

粉红粘帚菌的ATMT体系构建及定殖甘草条件优化