基于色谱指纹图谱的苍术挥发油多成分体内药代动力学研究

陶野; 张贝贝; 付梅红; 许海玉; 方婧; 王维皓; 李德凤; 张毅; 杨洪军

doi:10.11653/syfj2013110156

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基于色谱指纹图谱的苍术挥发油多成分体内药代动力学研究

更新时间：2024-01-04

- 基于色谱指纹图谱的苍术挥发油多成分体内药代动力学研究
- Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint
- 中国实验方剂学杂志 2013年19卷第11期页码：156-159
- 作者机构：
- 作者简介：
- 基金信息：
  
  中国中医科学院基本科研业务费自主选题课题(Z02063);国家科技支撑计划项目(2008BAI51B03)
- DOI：10.11653/syfj2013110156
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- 纸质出版日期：2013
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陶野, 张贝贝, 付梅红, 等. 基于色谱指纹图谱的苍术挥发油多成分体内药代动力学研究[J]. 中国实验方剂学杂志, 2013,19(11):156-159.

TAO Ye, ZHANG Bei-bei, FU Mei-hong, et al. Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 156-159.
陶野, 张贝贝, 付梅红, 等. 基于色谱指纹图谱的苍术挥发油多成分体内药代动力学研究[J]. 中国实验方剂学杂志, 2013,19(11):156-159. DOI： 10.11653/syfj2013110156.

TAO Ye, ZHANG Bei-bei, FU Mei-hong, et al. Studies on Pharmacokinetics of Multi-constituents of Atractylis Oil based on Chromatographic Fingerprint[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 156-159. DOI： 10.11653/syfj2013110156.

摘要

目的: 建立了茅苍术挥发油中7个成分的体内分析方法。方法: 采用内标法测定了给药后不同时间点7个化合物的血药浓度

并通过DAS 3.0软件计算出药代动力学参数

以自定义各成分的权重系数进行茅苍术挥发油整合药代动力学研究

分别获得化合物 1~7 及其整合的血浆浓度-时间曲线

化合物 2~7 和整合的药动学参数。结果: 整合药动学参数T1/2

Tmax

Cmax

AUC(0-∞)和MRT(0-∞)分别为8.01

4.00 h

3.84 mg·L-1

42.31 mg·L-1·h-1

11.65 h。结论: 研究思路符合中医药作用特点

对多组分苍术挥发油的药代动力学做了一些初步的探索。

Abstract

Objective: To investigate pharmacokinetics process of the major components of Atractylodes lancea oil in rats. Method: A preliminary HPLC method based on internal standard method was employed to analysis 7 constituents simultaneously in plasma and to study their pharmacokinetics after oral administration of volatile oil from A. lancea in rats. Pharmacokinetic parameters of compound 2~7 were acquired by DAS 3.0 software and the integrative concentration-time curve was obtained based on the corresponding weighting coefficients. Result: Integrative pharmacokinetic parameters was as follows: T1/2 was 8.01 h

Tmax was 4.00 h

Cmax was 3.84 mg·L-1

AUC(0-∞) was 42.31 mg·L-1·h-1 and MRT(0-∞) was 11.65 h

respectively. Conclusion: This study was thought as an appropriate method for traditional Chinese medicine and we carried out some exploratory survey for pharmacokinetics of volatile oil from A. lancea.

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