Objective: To investigate the therapeutic effect of Chuanping compound on guinea pigs with asthma. Method: All guinea pigs were given intraperitoneal injection of ovalbumin(OVA)and forced inhalation of atomized OVA to induce asthma. From the 14th day of modeling

the treatment groups were given the corresponding drugs according to the experimental design

ephedra groups (0.20 g·kg-1)

datura flower group (0.07 g·kg-1)

Chuanping compound group (0.32 g·kg-1)

dexamethasone group (7.5×10-4 mg·kg-1)

and the normal group and model group were given normal saline(NS)

once a day for 7 days. The general state of the guinea pigs and the changes of immunoglobulin E(IgE);transforming growth factor-beta 1 (TGF-β1) and tumor necrosis factor-alpha (TNF-α) in bronchoalveolar lavage fluid (BALF)were observed. Result: The levels of IgE

TGF-β1 and TNF-α in BALF of guinea pigs: normal group IgE(68.25±5.92) mg·L-1

TGF-β1(78.72±10.92) ng·L-1

TNF-α(388.02±55.61) ng·L-1); model group IgE(137.28±14.38) mg·L-1

TGF-β1(172.39±14.04) ng·L-1

TNF-α(752.76±51.25) ng·L-1;Chuanping compound group IgE(76.35±6.22) mg·L-1

TGF-β1(115.76±9.17) ng·L-1

TNF-α(569.32±39.7) ng·L-1;The levels of IgE

TGF-β1 and TNF-α in BALF of the model group and Chuanping compound group were higher than those in the normal group. After treatment

IgE

TGF-β1 and TNF-α levels in BALF of chuanping group were lower than those in the model group. Conclusion: Chuanping compound has an effect of reducing airway hyperresponsiveness

alleviating airway inflammation

controlling or delaying the process of airway fibrosis through up-regulation of IgE

TGF-β1 and TNF-α levels in BALF of guinea pigs.