Objective: To explore the effects of the compatibility of Panax notoginseng saponinsn and icariin on high glucose-induced proliferation inhibition of osteoblasts. Method: The third-fifth generation cells were taken as experimental model

osteoblast density was 1×105/mL

the growth of the osteoblasts was observed when glucose (Glu) concentrations were 20

40

60 mmol·L-1.The concentration of P. notoginseng saponins and icariin were 10

20

50

100 mg·L-1

MTT was applied to determine the protective effect of high glucose-induced proliferation inhibition of osteoblasts. Result: Compared with control group

the growth of the osteoblasts was significantly inhibited when Glu concentrations was 60 mmol·L-1 (P<0.05

P<0.01).P. notoginseng saponins and icariin in a dose of 10

20

50 mg·L-1 had significantly protective effect of high glucose-induced proliferation inhibition of osteoblasts(P<0.05

P<0.01).When the component formula of P. notoginseng saponinsn and icariin was 50 mg·L-1: 20 mg·L-1

compared with control group

the component group can promote proliferation of osteoblasts(P<0.01). Conclusion: The compatibility of P. notoginseng saponinsn and icariin was feasible in the protective effect of high glucose-induced proliferation inhibition of osteoclasts.