Objective: Comparing urine reduction of Fructus Alpiniae Oxyphyllae (FAO) after stir-frying with salt water in water-loading diuresis model rats

so as to prove the correction of traditional processing theory that the FAO would effect on kidney after salt processing. Method: According to the weight and volume of urine

Sprague Dawley rats were divided into 9 groups: normal group; model group; Suoquanwan group; low

middle and high dose group of FAO before and after salt processing. The dose of Suo Quan Wan group was 1.5 g·kg-1. The dose of low

middle and high dose group of FAO before and after salt processing was 4.5

9

18 g·kg-1 of raw FAO respectively. The metabolism cage method was used to determine the urine volume and the initial excretion time of rats. The excretion rate in 6 h was calculated

and (AVP) content in rat serum was determined by radioimmunoassay. Result: Compared with the model group

FAO before and after salt processing groups(in addition to FAO low dose group) could reduce volume of urine in 0-1 h significantly(P<0.01)

and prolong the first excretion time(for high dose group of FAO

P<0.05; for low

middle

high dose group of FAO after salt processing

P<0.01)

and also decrease excretion rate in 6 h significantly(for high dose group of FAO

P<0.05; for high dose group of FAO after salt processing

P<0.01). Compared with model group

the content of AVP of each group was increased

and high dose group of raw FAO

middle and high dose group of FAO after salt processing had significant difference (P<0.01). Conclusion: Fructus Alpiniae Oxyphyllae has the effect of urine reduction

and this effect could be enhanced after salt processing.