Objective: To investigate the influence of the total flavones from Carambola leaf (TFCL) in decreasing blood sugar level in animals with diabetes mellitus (DM). Method: DM mouce model was induced by abdominal injection of alloxan 80 mg·kg-1 and DM rat model was induced by abdominal injection of streptozocin 40 mg·kg-1 respectively. Successful model animals confirmed by detecting fasting blood-glucose were randomly divided into 5 groups: normal control group (distilled water)

model group (distilled water)

glibenclamide group (0.3 g·kg-1)

high

medium and low dosage groups of TFCL (0.8

0.4

0.2 g·kg-1). The drugs were given daily for 7 consecutive days. After 1.5 h of last administration of drugs

the influence of TFCL on blood sugar level in DM mice and rats was observed. Result: TFCL (high and medium dosages) could decrease the blood sugar level and enhance glucose tolerance significantly in DM mice and rats. Conclusion: TFCL has hypoglycemic and enhancing glucose tolerance effects in DM mice and rats.