Objective: To investigate the clinical effect of Yitangkang by analyzing the changes in the glucose metabolism

lipid metabolism and blood pressure

body mass index (BMI) and other parameters for patients with impaired glucose regulation (IGR)

metabolic syndrome (MS) and phlegm-heat interties using glycosylated hemoglobin (HbA1c) 6.5% as the cut off point. Method: Multi-centered 165 patients with MS and IGR were selected and divided into two groups (n=82)

patients in treatment group were given Yitangkang

patients in control group(n=83) were given placebo

all the patients were treated for 12 weeks

the HbA1c

fasting plasma glucose(FPG)

postprandial 2 h glucose

total glycerin (TG)

total cholesterol (TC)

low density lipoprotein cholesterol(LDL-C)

high density lipoprotein cholesterol(HDL-C)

blood pressure(BP)

BMI before and after treatment were detected and statistical analyzed with HbA1c 6.5% as the cutoff point. Result: Patients with IGR

MS and phlegm-heat interties accounted 120 cases (75%) as HbA1c<6.5%. The 2 hPG and BP of treatment group were decreased (P<0.05) no matter the HbA1c level. FPG and TG could decrease by Yitangkang when HbA1c≥6.5%; TC levels could decrease by Yitangkang when HbA1c<6.5% (P<0.05). Conclusion: Yitangkang

the Chinese herbal compound

can significantly improve glucose and lipid metabolism parameters for patients with IGR and MS

and can regulate the BP and BMI and also plays different roles at different HbA1c layers.