Objective: To observe the clinical effect of the treatment of Jianpi Huayu Jiedu for the patients with chronic atrophic gastritis and its influence on the Cyclin E protein expression. Method: Sixty cases were divided into control group and treatment group (n=30 each) randomly. Another 10 persons were selected as the healthy controls. The patients in the control group were given Weifuchun tablets of 4 tid. The cases in the treatment group were received Jianpi Huayu Jiedu decoction (one decoction divided taken 3 times daily). Clinical effect

endoscopic images

pathological changes and the effect on helicobacter pylori (HP) were observed in each group. The expression of Cyclin E protein in every group was investigated using immunohistochemistry. Result: The total effect in treatment group was 93.33%

that of the control group was 86.67%

having no significant difference. The endoscopic images (80.00%)

pathological changes (76.67%) and the HP eradication rate (68.18%) in the treatment group were better than those (60.00%

60.00% and 21.05%) in the control group

having significant difference (P<0.05). The expression of Cyclin E protein was decreased after treatment in the both treatment group and control group

and the treatment group was also better than control group

with significant difference (P<0.01). Conclusion: The treatment of Jianpi Huayu Jiedu can influence the expression of the Cyclin E protein in the patients with precancerous lesion of gastric carcinoma

so it may prevent the development of precancerous lesion of gastric carcinoma.