Objective: To observe the clinical effects of the treatment based on differentiation of liver and blood stasis for sedative hypnotics dependence insomnia. Method: One hundred and twenty subjects were randomly divided into two groups. control group was given estazolam

1-6 mg

qn; Qianyang Huoxue was added to the treatment group

all for 8 weeks. Daytime function and the usage amount of estazolam were observed. Result: The incidence of daytime dysfunction of the treatment group was more lower than control group (P<0.05); the average amount of estazolam given between treatment group (1.47±1.28) mg was lower than that in the control group (4.05±1.59) mg (P<0.01). The total effective rate of treatment group (93.3%) was higher than the control group (70%) (P<0.05). Conclusion: Qianyang Huoxue decoction can significantly improve daytime function of sedative hypnotics dependence insomnia and reduce the dosage of anti-psychotic drugs so as to enhance clinical effects.