Eighteen incompatible pairs is a set of strict incompatibility formed at opposite basis

however

many combination of two incompatible herbs are applied in clinical to treat disease from the ancient time to today. Combination of two incompatible herbs are opposite or counter

there are many disputes in modern property theory

and has not formed a unified and objective judgment standard. Through the literature review

Glycyrrhiza co-administered with Sargassum pallidum

Euphorbia pekinensis

E.kansui and Daphne genkwa are introduced from the clinical application

preparation and administration

compatibility proportion

cytochrome P450 and toxicological aspects

pointing out that the past study of Glycyrrhiza co-administered with S.pallidum

E.pekinensis

E.kansui and D.genkwa focus on long-term toxicity

acute toxicity

and experimental study of specific site is very few

and experimental conditions are not unified phenomenon

such as drug source

mode of delivery

compatibility proportion.This paper presents that experimental conditions should be standardized to reduce all kinds of uncertain factors

and system study should be carried out based on the characteristics of different drugs from specific parts

in order to accurate medication of Glycyrrhiza co-administered with S.pallidum

E.pekinensis

E.kansui and D.genkwa and further research with literature foundation.