CHEN Xiao-xia, XIANG Xiao-qing, YE Hong. Progress of Research and Application in Tumors of Matrine and Oxymatrine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 361-364.
CHEN Xiao-xia, XIANG Xiao-qing, YE Hong. Progress of Research and Application in Tumors of Matrine and Oxymatrine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(11): 361-364. DOI: 10.11653/syfj2013110361.
The Chinese traditional medicine sophora avescens aiton is the dry root of leguminous plant radix sophorae flavescentis
the early researches showed that
as the main active component
matrine and oxymatrine have the functions of anti-inflammation
arrhythmia and
anti-virus. Further studies found that they also can kill tumors
and its antitumor activity mainly displays in inhibiting proliferation and metastasis
inducing differentiation and apoptosis
promoting apoptosis
inhibiting telomerase activity
inhibiting the formation of new blood vessels
inhibiting the drug resistance
promoting antitumor immune response of the host and so on. In addition
studies confirm that matrine and oxymatrine can obviously improve the cachexia state and improve the patients' quality of life. Matrine and oxymatrine are natural plant drugs