Objective: To optimize formula of gastric floating tablets of total glucosides from Centella asiatica. Method: Gastric floating tablets were prepared by direct compression with dry powder.With floating properties and in vitro release as indexes

single factor tests and mixture design test were adopted to optimize formulation parameters which impacted properties of gastric floating tablets of total glucosides from C. asiatica. Result: Optimum formulation included 25% total glucosides from C. asiatica

28.6% HPMC K15M

15.6% NaHCO3

20.8%CMS-Na and 10%PEG20000.The results showed that these products could float within (3.2±0.2) min and maintain for over 12 h

in vitro release of this tablets fitted zero-order kinetics model. Conclusion: These prepared gastric floating tablets showed a good sustained-release and continual floating property

it could increase residence time and improve efficacy for gastric ulcer.