Objective: To prepare curcumin-loaded mPEG114-PCL36 nanomicelles and investigate its in vitro release. Method: mPEG114-PCL36 block copolymer was synthesized by ring-opening polymerization method and its structures was identified by FT-IR and 1H-NMR

the critical micelle concentration was detected by fluorescence techniques with pyrene as a probe.Polymer micelles containing curcumin were prepared by dialysis

effects of the concentration of copolymer and curcumin

volume ratio of aqueous phase to organic phase on particle size of micelles

entrapment efficiency and drug loading was evaluated by orthogonal design.Eencapsulation efficiency and drug loading were determined by HPLC

particle size was examined by laser light scattering

dynamic dialysis method was used to investigate in vitro release characteristic of nanomicelles. Result: Average particle size of these prepared nanomicelles was (48.5±1.7) nm with polydispersity index of (0.20±0.07)

drug loading of (49.12±1.26)% as well as encapsulation efficiency of (4.46±0.12)%.In vitro cumulative release of curcumin nanomicelles in 72 h was 41.9% and without significant burst release at initial stage. Conclusion: These prepared curcumin-loaded nanomicelles showed a good sustained-release property with small and evenly distributed particle size.