祖师麻总香豆素纯化工艺优选

李开; 尹蓉莉; 孔艳; 张立; 朱双燕; 陈柳钦

doi:10.11653/syfj2013120058

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祖师麻总香豆素纯化工艺优选

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- 祖师麻总香豆素纯化工艺优选
- Optimization of Purification Technology of Total Coumarins in
- 中国实验方剂学杂志 2013年19卷第12期页码：58-60
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- DOI：10.11653/syfj2013120058
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- 纸质出版日期：2013
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李开, 尹蓉莉, 孔艳, 等. 祖师麻总香豆素纯化工艺优选[J]. 中国实验方剂学杂志, 2013,19(12):58-60.

LI Kai, YIN Rong-li, KONG Yan, et al. Optimization of Purification Technology of Total Coumarins in [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 58-60.
李开, 尹蓉莉, 孔艳, 等. 祖师麻总香豆素纯化工艺优选[J]. 中国实验方剂学杂志, 2013,19(12):58-60. DOI： 10.11653/syfj2013120058.

LI Kai, YIN Rong-li, KONG Yan, et al. Optimization of Purification Technology of Total Coumarins in [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(12): 58-60. DOI： 10.11653/syfj2013120058.

摘要

目的: 优化祖师麻总香豆素的纯化工艺。方法: 以总香豆素含量为指标

采用静态和动态吸附-洗脱试验筛选大孔树脂型号

通过单因素试验考察最大上样量、洗脱剂浓度和用量、洗脱速度对纯化工艺的影响。结果: AB-8型大孔树脂对总香豆素的吸附性能和解析效果最佳

其最佳纯化工艺为最大上样量3 BV

加去离子水洗脱杂质

用75%乙醇10 BV洗脱

洗脱流速2 BV·h-1。结论: 优选的纯化工艺稳定可靠

能满足祖师麻总香豆素渗透泵控释片需求。

Abstract

Objective: To optimize purification technology of total coumarins in Daphne giraldii. Method: With the content of total coumarins as index

model of macroporous resin was screened by static and dynamic adsorption-elution test

effect of the maximum sample volume

the concentration and amount of eluent

elution speed on purification technology was investigated by single-factor test. Result: AB-8 resin showed the best due to its adsorption and desorption properties

optimum purification conditions were as follows:the maximum sample volume 3 BV

added deionized water for removing impurities

and eluted with 10 BV of 75% ethanol at the flow rate of 2 BV·h-1. Conclusion: This optimized technology was stable and reliable

which could meet requirements of total coumarins in D. giraldii osmotic pump tablets.

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